Endocrine Abstracts

The purpose of the present study was to elucidate expressions of ERβ1 and ERβ2 expression in papillary thyroid cancer (PTC). ER β splicing variants expressions were examined on formalin-fixed, paraffin-embedded thyroid tissues from 106 PTCs and 30 nodular thyroid goiters (NTGs) by immunehistochemical methods using Elivision plus two-step system. There was significant difference in the subcellular localization of ERβ1 expression (P<0.001), but not...

Increased hypothalamic-pituitary-adrenal (HPA) activity in the fetus is a consistent event across different animal species, including the human. Fetal HPA activation contributes both to maturation of organ systems required for extra-uterine life and provides the trigger for the birth process. Precocious activation of the fetal HPA axis, for example in response to an adverse intrauterine environment or periconceptual undernutrition may result in increased incidence of preterm b...